|  | 04 Apr | 21:00 EAT | FC Koln vs Eintracht Frankfurt | 1-0 | 1 |
| | 04 Apr | 21:00 EAT | SV Werder Bremen vs Schalke | 3-0 | X2 |
| | 04 Apr | 21:45 EAT | Burnley vs Stoke City | 1-0 | X |
| | 04 Apr | 21:45 EAT | Watford vs West Brom | 2-0 | X |
| | 04 Apr | 22:30 EAT | Betis vs Villarreal | 0-1 | X2 |
| | 05 Apr | 18:30 EAT | Munich 1860 vs VfB Stuttgart | 1-1 | 2 |
| | 05 Apr | 19:30 EAT | Angers vs Bordeaux | 2-1 | X2 |
| | 05 Apr | 21:00 EAT | FC Augsburg vs Ingolstadt | 2-3 | 1 |
| | 05 Apr | 21:00 EAT | Mainz 05 vs RB Leipzig | 2-3 | 2 |
| | 05 Apr | 21:30 EAT | Gijon vs Malaga | 0-1 | 1 |
| | 05 Apr | 21:45 EAT | Hull City vs Middlesbrough | 4-2 | 1 |
| | 05 Apr | 21:45 EAT | Napoli vs Juventus | 3-2 | X2 |
| | 05 Apr | 22:00 EAT | Chelsea vs Manchester City | 2-1 | 1X |
